Monday, September 12, 2011

Auxiliary Liver Transplant

In patients with acute liver failure (ALF) who fulfil criteria, liver transplantation is the only effective treatment which can substitute metabolic and excretory function of the liver. Auxiliary liver transplantation was developed because a significant minority of patients with ALF who fulfil transplant criteria can have a complete morphological and functional recovery of their liver.
In the majority of cases the auxiliary graft is a right graft which is placed orthotopically after a right hepatectomy in the recipient. After standard immune-suppression, the recovery of the native liver is assessed by biopsies, hepatobiliary scintigraphy and computed tomography. When, on the basis of histological, scintigraphical and morphological data, there is evidence of sufficient regeneration of the native liver, immune-suppression can be discontinued progressively. Complete regeneration of the native liver can be observed in >50% of patients, who can be withdrawn from immune-suppression. Therefore the advantages of auxiliary transplantation seem to balance favourably with the potential inconvenience of this technique in selected patients.
Auxiliary liver transplantation entails attaching a portion of a healthy donor's liver to a portion of a recipient's diseased liver. The donor liver remains intact until the native organ recovers, at which point the diseased liver may be removed. This procedure now accounts for a substantial proportion of liver transplants in children today.

This technique is an innovative way to treat patients with acute liver failure, in order to allow the patient's own liver to recover. While liver transplantation requires patients to take immunosuppressant medications for the remainder of their lives, auxiliary partial liver transplantation does not. The procedure entails attaching part of a donor liver to the failing liver in the recipient, where it supports the patient, clears toxins, and prevents brain injury during recovery. After the patient's native liver recovers, the donor liver withers in most patients, and the majority of patients are able to withdraw from immunosuppressant medications.

This procedure is particularly suited to children because the regenerative capacity of their livers is optimal. This technique may also be applied in young adults. This is also an advantage to patients with genetic errors of metabolism because the function of their own liver is perfectly normal except for one genetic defect. Auxiliary liver transplants are preferred because the patient is not entirely dependent upon the transplanted liver, should it be rejected.
Auxiliary liver transplant provides temporary support until the native liver recovers and immune-suppression can be withdrawn. Once you’re diagnosed with a liver disease, your physician will be able to determine whether or not you require a liver transplant. The type of transplant that you should undergo will also be decided based on the condition of your liver.

Visit Hospitals in Chennai for more details.

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